| 
 Formula Ingredient Deck 
 | 
 Benefits Of Each Ingredient  
 | 
| 
 Vitamin B6 pyridoxal 5'-phosphate (PLP) 
 | 
- Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40).
 
- 
May support reduced plasma glucose (blood sugar levels) via inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39).
 
- 
Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40).
 
 
- May support blood sugar regulation in women with gestational diabetes (40).
 
- Cofactor for enzymes involved in DNA metabolism (40).
 
 
 | 
| 
 Niacin (Vitamin B3) 
 | 
- Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reduced very-low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (8,9,10,11).
 
- May reduce conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (8,9,10,11).
 
- Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (8,9,10,11).
 
- 
May support healthy inflammatory responses via antioxidant and anti-apoptotic (prevention of cell death) properties (8,9,10,11)
 
 
- 
May support cognitive health by reducing the age-related decline of NAD+, increasing quinolinic acid, and reducing neuroinflammation (8,9,10,11).
 
 
- 
Increased niacin-associated NAD+ levels have been shown to support neurotransmission, learning, and memory (8,9,10,11).
 
 
- Niacin may reduce the prevalence of neurodegenerative pathologies by supporting mitochondrial dysfunction (8,9,10,11).
 
 
 | 
| 
 Caffeine Anhydrous  
 | 
- May support optimized energy, cognitive function, and mental alertness (24).
 
- Supplementation with caffeine has been shown to acutely enhance exercise performance (24).
 
 
 | 
| 
 L-Citrulline Malate 
 | 
- May support cardiovascular health and exercise performance by increasing the production of l-arginine (34).
 
- 
May support increased nitric oxide production, improved exercise performance, and increased blood flow to exercising skeletal muscle (35).
 
- 
May support strength increases, exercise endurance, and recovery (34,35).
 
- May support reduced blood pressure by increasing vascular function (34).
 
 
 | 
| 
 Vitamin B-12 (Methylcobalamin) 
 | 
- 
May support  proper DNA synthesis, folate cycle function, energy production, cognitive function, and immune health (51,53).
 
 
- Aids as an antioxidant via direct scavenging of reactive oxygen species (inflammation), preserving l-glutathione levels (master antioxidant), and reducing oxidative stress (51).
 
- May support reduced vitamin b-12 deficiency pathologies such as anemia, neurodegenerative disease, cardiovascular disease, and osteoporosis (53).
 
 
 | 
| 
 Creatine Monohydrate  
 | 
- 
Optimizes exercise performance, muscle mass, strength, thermoregulation, recovery, and intramuscular stores of phosphocreatine (PCr) (47).
 
 
- Vital for the energy reaction of every cell in the human body as a spatial energy shuttle and energy sensor (47,50).
 
- Vital in bioenergetics (metabolic activity) of the brain (50).
 
- 
Fuels CD8 and CD4 T- cell-mediated immunity (immune cells) (48,49).
 
 
- 
May support cognitive health in brain creatine deficiency associated with neurodegenerative diseases (50).
 
 
- 
May support cognitive health by enhancing the facilitation of synaptic glutamate and neurotransmitter uptake (50).
 
 
 | 
| 
 Vitamin B2 
 | 
 
  
 
 | 
| 
 Vitamin B1 
 | 
- May support aerobic energy metabolism (oxidative phosphorylation), cell growth, optimal neuronal conduction (nerve impulses), and cardiovascular health (94).
 
- 
May support cardiovascular function and aids as a neuroprotective agent in individuals with vitamin B-1 deficiencies (94, 95). 
 
 
 
 | 
| 
 Vitamin B5 
 | 
- 
May support energy production, cell growth, cell repair, cognitive function, increased hippocampal volume (memory), and optimized bioenergetics (burning of carbohydrates, fat, and protein) (96). 
 
 
 | 
| 
 Vitamin C 
 | 
- 
May support immune, cardiovascular, skin, cognitive, fat burning, and digestive health (97, 98).
 
- May support immune health via increased oxidant, free radical scavenging, and fueling neutrophilic (immune cell) activity in chemotaxis, phagocytosis, and microbial killing (97,98).
 
- May support fat burning by increasing carnitine biosynthesis (molecule required for mitochondrial fatty acid oxidation) (97,98).
 
- 
May support accelerated bone healing after a fracture, increased type I collagen synthesis, and reduced oxidative stress (inflammation) (98).
 
 
 
 | 
| 
 Betaine Anhydrous 
 | 
- 
May support healthy digestion, protein metabolism, and balanced stomach acid levels in aging adults (370).
 
 
- 
May support reduced prevalence of obesity via improved gut microbiome activity (371).
 
 
 
 | 
| 
 Dynamine  
 | 
 | 
| 
 GABA 
 | 
- 
May support  positive mood, increased memory, reduced anxiety, blood sugar regulation, and increased growth hormone production (102).
 
 
 
 | 
| 
 Beta Alanine 
 | 
- 
May support improved exercise performance, increased nutrient delivery to exercising muscle, and reduced lactate-associated neurological exercise fatigue (15).
 
 
- 
May support reduced carnosine (muscle acidity) levels and acts as an intramuscular ph buffer (15).
 
 
- May support reduced lactate “burn” associated fatigue during extreme exercise (15).
 
 
 |